The i2b2 tranSMART Foundation offers i2b2 and tranSMART, modular open source software for query, exploration and analysis of clinical, translational and genomics data. What makes them different is their flexible, ontology-driven architecture and community-developed plugins and interfaces that enable a variety of configurations to support the needs of data scientists, academic clinical investigators, and industry.
Informatics for Integrating Biology & the Bedside, or i2b2 is an NIH-funded enterprise clinical research platform, which contains a database model, application layer, and core APIs.

The i2b2 Software

tranSMART is a suite of data exploration, visualization, genomic analyses and ETL tools, which were developed by pharma for translational research studies.

The tranSMART Software

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Solutions and Use Cases

Patient Recruitment Use Case

One of the most common uses of the Foundation’s platforms is in the exploration and identification of a patient cohort for a particular study.  The ability to easily look across a wide range of patient information for particular symptoms, medical history, genomic profile, etc. and review and analyze the resulting sets of patients make our platforms useful for clinicians and research teams.

For example, large hospitals and medical centers load data on millions of patients into i2b2 to evaluate clinical trial feasibility and to accelerate patient recruitment. Through a web-based query tool, investigators can define complex inclusion and exclusion criteria, apply temporal and value-based constraints, and access patients’ notes and biobank data.

The Use Case Working Group is compiling sets of examples that will be linked to this site in the near future.

Translational Studies Use Case

Translational studies use the PIC-SURE software to integrate clinical and genomic data from multiple sources. Clinicians and data scientists explore and analyze the data with tranSMART and tools from 3rd party companies such as the hyve. Users can also query the PIC-SURE APIs programmatically through software such as jupyter and connect to hail for large scale genomic research.

One of the new components is the PIC-SURE interface that provides integration as well as allows users to query the data programmatically through software such as Jupyter and to connect to other data repositories such as Hail for large scale genomic research.

Federated Networks Use Case

Institutions that map their local coding systems to a common ontology can use the SHRINE software to build federated data networks, which protect patient privacy by keeping the data within each hospital’s local i2b2 database. The largest SHRINE networks contain data on more than 100 million patients, enabling large population-wide studies.

It is important to note that these different architectures can be combined, so that an institution can use the same i2b2 core database for more than one use case. This flexibility is what makes i2b2 tranSMART unique and is a main reason why the platform has been adopted by more than 200 institutions worldwide.

Components and Plugins

Solutions

Numerous plugins and 3rd party products have been developed to extend the functionality of i2b2 and tranSMART; and, although institutions have the flexibility to use their own data sources and local medical coding systems, they also have access to a variety of resource libraries that provide standardized ontologies, example datasets and data loading tools to help them get started.

View a 30-second overview

Video created by Griffin Weber

What is i2b2 and tranSMART?

Modular open-source software platforms for query, exploration, and analysis of clinical, translational, and genomics data.

  • What makes them different?

    The flexible, ontology-driven architecture and community-developed plugins and interfaces enable a variety of configurations to support the needs of data scientists, academic clinical investigators, and industry.

  • Where did i2b2 tranSMART come from?

    They brings together an NIH-funded enterprise clinical research platform (i2b2) and pharma-developed software for translational research studies (tranSMART).

Many tools exist for working with these types of data, but what makes i2b2 tranSMART different is a flexible ontology-driven architecture and community developed plugins and interfaces, which enable a variety of configurations to support the needs of data scientists, academic clinical investigators, and industry.

View a 3-minute description of our Products and Solutions

The modular architecture of i2b2 and tranSMART supports many use cases.

i2b2 tranSMART Foundation

To learn more or get further information on how you can contribute to i2b2/tranSMART, review our website: