i2b2 release 1.8.2 is now available!
This major open-source update is packed with critical upgrades, performance enhancements, and powerful new features to support clinical and translational research worldwide.
What you you can expect:
- Secure Software Framework updates
- Faster Patient Counting Scripts
- ACT Ontology v4.2 Integration
- New Data Export Workflow
- Enhanced Performance
i2b2 tranSMART Chairman of the Board
Congratulations to Zak on the recent publication of The AI REVOLUTION in MEDICINE: GPT-4 AND BEYOND and added title of Editor-In-Chief of a new journal from the New England Journal of Medicine entitled NEJM AI


Isaac Kohane, MD Ph D
Chair of the Department of Biomedical Informatics, Harvard Medical School
Marion V. Nelson Professor of Biomedical Informatics, Harvard Medical School
Associate Professor of Medicine, Brigham and Women’s Hospital
Impact Genome Insight (Jan 2026)
The I2B2 Foundation supports healthcare systems in incorporating their Computational Phenotype Pipeline into their work to support research. To date, six hospitals have adopted the system, which enables them to access an open-source database and advanced analytics that were not previously available. The use of this system will increase efficiency in medical research, which will be the focus of additional evaluation in the future.
Click the Impact Verified logo to see our Verified Impact Report.
With generous support from


Diane Keogh
Executive Director
Diane.Keogh@i2b2transmart.org
From The Executive Director’s Desk
Welcome to an Exciting 2026!
This year promises to be a transformative one as we continue our mission of advancing translational research through cutting-edge technology, global collaborations, and community-driven initiatives.
Strategic Updates from Our Board of Directors
Our Board of Directors remains a cornerstone of our success, guiding us with expertise from academic medical centers and industry leaders across the U.S. and Europe. Their strategic vision drives innovation and strengthens our foundation’s global impact.
➡ Meet our Board members Click HERE
Revolutionizing Healthcare with Dell Technologies
We are thrilled to extend our collaboration with Dell Technologies, which supports the groundbreaking Personalized Digital Medical Twin initiative.
Key Highlights:
- Explainable AI Integration: Harnessing transparent AI for more accurate patient representations, paving the way for precise cohort identification in clinical trials.
- Computed Phenotypes in Action: i2b2 v1.8.1 introduces algorithms that deliver deeper insights into patient conditions and empower clinical decision-making.
Expanding Horizons with the EnACT Network
The rollout of i2b2 v1.8.2 across the EnACT network marks a significant milestone, extending the reach of computational phenotypes and advancing translational research nationwide.
We Want to Hear from You!
Your input drives our success. Share your thoughts, join our initiatives, or simply reach out.
➡ Contact us: Click HERE


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