June 22-23, 2021

i2b2 tranSMART Virtual Symposium

Supporting  Sequelae of COVID-19



Keynote Speakers


Josh Mandel, MD

FHIR: Interop for Consumer Access, Clinical Research, and Beyond: As Chief Architect for Microsoft Healthcare, Chief Architect for SMART Health IT, and Lecturer at the Harvard Medical School Department of Biomedical Informatics, Josh works closely with the standards development community to lay groundwork for frictionless data access, authorization, analytics, and app integration.

 Event highlights – Save the date! 

June 22nd

Sponsor updates
Use Cases
  • Deploying i2b2 using Snowflake on Amazon
  • PCORNet CDM using Snowflake on AWS
  • More use cases to come!
  • Kenneth Mandl, Professor of Pediatrics and Professor of Biomedical Informatics, Harvard Medical School
  • Josh Mandel, Chief Architect, Microsoft Healthcare and SMART Health IT
4CE International Consortium
Committee on Technology
  • DELL Project Update
  • i2b2 tranSMART Roadmap

June 23rd

Working Group Updates
  • ETL
  • Ontology
  • User Interface
Network Strategy Session

Thank you to all of our Sponsors for your continued support!

More information on this two day event will be coming soon, save the date!

Executive Director DBMI, Harvard Medical School

Dr. Churchill is executive director of DBMI, and the Big Data to Knowledge (BD2K) Center of Excellence. Dr. Churchill also serves as the executive director of the N-GRID (neuropsychiatric genome-scale and RDoC-Individualized domains). She also serves at the Center of Excellence in Genome Science and program director for the Summer Institute in Biomedical Informatics

more about Dr. Churchill

Isaac Kohane, MD Ph D

Professor & Chair of the Department of Biomedical Informatics at Harvard Medical School

Board Chairman of the i2b2 tranSMART Foundation

more about Dr. Kohane

A Message from Isaac Kohane

Right from the start, in March 2020, it was clear that there were going to be numerous international research studies collecting and analyzing data on COVID-19 patients. But those of us with experience with system-wide data, particularly EHR-derived data knew that we were facing a tall order. We had to move fast because the need was urgent. Yet, given the heterogeneity of our institutions and practices, how could we develop a reliable big picture of what was happening to our patients? Launched in March, 2020, 4CE is a unique project that engages local experts in informatics, statistics and clinical medicine at more than 350 hospitals across 9 countries on 4 continents to iteratively improve sites’ data quality, understand the limitations of EHR data on COVID-19 patients, and conduct rapid analyses through a federated model that reduces barriers to participation. We believe that early intelligence is worth more than complete intelligence later. Our goal is to move quickly, publish results, and share lessons learned with others.

Next Community Meeting

Informatics for Integrating Biology & the Bedside, or i2b2 is an NIH-funded enterprise clinical research platform, which contains a database model, application layer, and core APIs.

The i2b2 Software

tranSMART is a suite of data exploration, visualization, genomic analyses and ETL tools, which were developed by pharma for translational research studies.

The tranSMART Software

Common Data Model for i2b2 and tranSMART

COVID-19 4CE Consortium

Dr. Zak Kohane and several members of our Board of Directors have launched an urgent initiative with organizations around the world to rapidly collect aggregate data on hospitalized patients that are COVID-19 positive. The goal of this effort is to quickly collect data and publish the results.
Consortium for Clinical Characterization of Covid19 by EHR (4CE)

In this time of great need, the i2b2 tranSMART Foundation and the i2b2 community are working to combine national and international data for analyses of the COVID-19 affliction on our patients.

The 4CE Consortium is a globally distributed collaboration across health centers. In this first phase we are reaching out to other collaborators to join our 96 hospital collaboration who also have EHR data to share to augment the breadth and depth of the analyses we jointly work on.

Connect to 4CE

About the i2b2 tranSMART Foundation


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Diane Keogh
Executive Director

From The Executive Director’s Desk

COVID-19 Action!

In this time of great need, the i2b2 community is working to combine national and international analyses of the COVID-19 affliction on our patients.

There are two major initiatives that the Foundation is participating in at this time.

Grant to the Foundation from Dell Technologies

First, we are delighted to announce that Dell Technologies has given the Foundation a significant grant to expedite three projects that are focused on COVID-19 research working towards better understanding diagnosis, treatment and prevention of the disease. The three projects will be described in detail in upcoming Community Meetings. They are:

  • Public tranSMART v19 platform running on AWS with datasets that become publicly available. This project is in collaboration with Axiomedix.
  • With the explosion of articles and research labs studying the corona virus (over 6,000 articles from 25,000 authors), a special version of Profiles is being developed by Griffin Weber and will be available publicly.
  • i2b2 and tranSMART are being synchronized to the same data model so that direct data sharing will be possible between the Foundation platforms. We will have a few use cases and sample deployments available in the coming months.

4CE Consortium

Second, I want to tell you about the 4CE Consortium that was launched by Dr. Zak Kohane and several members of our Board of Directors. This urgent initiative with organizations around the world allowed labs with i2b2 to rapidly collect aggregate data on hospitalized patients that are COVID-19 positive. Their first publication is available as a preprint (click here) and will be published soon.

i2b2 ACT COVID ontology that has been developed

An initial ACT COVID ontology has been developed by the ACT Harmonization Committee. Note: Implementing this ontology is not necessary for this initial submission, but it might be helpful for you to look at the codes it uses as you try to identify your population of COVID-19 positive patients. click here for ACT COVID ontology

More information will be published here on our website as it becomes available. Be sure to join our Community Meetings and please attend the 2020 Harvard Virtual Symposium which will include focused sessions on these and other COVID-19 related projects.


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Next Community Meeting May 18th, 11:00 AM EST
Agenda and meeting link here https://conta.cc/2QfWlCw
June Virtual Symposium to focus on Supporting Sequelae of COVID-19. #datasharing #COVID19 #LongCovid #clinicalresearch

"Dell announced a collaboration with i2b2 transSMART Foundation to create and study digital twins of tens of thousands of long-haul COVID-19 patients." https://www.axios.com/newsletters/axios-future-5c33c671-984c-488b-8ca5-b6befc9e51fe.html?chunk=2&utm_campaign=axios_app#story2 #datasharing #COVID19 #clinicalresearch

Technology has kept the world running, but just as inspiring is how it is moving the world forward and enabling us to track the long-term health effects of COVID-19 in a fraction of the time ever before imagined.

4CE mentioned in The Role of Artificial Intelligence in Fighting the COVID-19 Pandemic. https://link.springer.com/article/10.1007/s10796-021-10131-x #clinicalresearch #covid19 #EHR #datasharing #4CE

Development of a COVID-19 Application Ontology for the ACT Network - connected to i2b2 https://academic.oup.com/jamiaopen/advance-article/doi/10.1093/jamiaopen/ooab036/6237901
#covid19 #EHR #clinicaltrials

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