AMIA  2021 -San Diego

October 30 – November 3


We hope to see you there!


AMIA Registration

Foundation Members Presenting

Oct 30, 2021 1:00 PM – 4:30 PM PDT W15: Introduction to analysis of EHR and OMOP databases using the i2b2 platform – Michael Mendis, Jeffery Klann, Shawn Murphy, Kavishwar Wagholikar

Nov 01, 2021 8:30 AM – 10:00 AM PDT S20: Panel – Temporal Phenotypic Pathways of Post-Acute Sequelae of SARS-CoV-2 by an International Consortium for Clinical Characterization of COVID-19 (4CE) – Shawn Murphy, Riccardo Bellazzi, John Holmes, Hossein Estiri, Arianna Dagliati

Nov 03, 2021 8:30 AM – 10:00 AM PDT S89: Systems Demonstrations – Data Analytics and AI – Jeffery Klann

Program Schedule

Consortium for Clinical Characterization of COVID-19 by EHR

4CE is an international consortium for electronic health record (EHR) data-driven studies of the COVID-19 pandemic. The goal of this effort—led by the i2b2 international academics users group—is to inform doctors, epidemiologists and the public about COVID-19 patients with data acquired through the health care process.

Within the first months of the COVID pandemic 4CE pulled together members from existing i2b2 and OMOP networks to immediately stand up the consortium to examine patient data from electronic health records across North American, Europe, Asia, and South America to begin to understand clinical practices and patient outcomes. This conference will examine the achievements, the 4CE dissemination “package”, and how 4CE is positioned to link with other complementary efforts.   ~ Isaac Kohane

Registration now open!

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Program Schedule

Informatics for Integrating Biology & the Bedside, or i2b2 is an NIH-funded enterprise clinical research platform, which contains a database model, application layer, and core APIs.

The i2b2 Software

tranSMART is a suite of data exploration, visualization, genomic analyses and ETL tools, which were developed by pharma for translational research studies.

The tranSMART Software

Common Data Model for i2b2 and tranSMART


Next Community Meeting

AI-Enabled Learning Healthcare Platform
Read Full Article
This new AI-driven platform will help health care professionals use the explosion of research findings to deliver better care and precision treatments for their patients. Dr. Shawn Murphy, i2b2 tranSMART Foundation Board Member.

June 2021


Presentations and Recordings

slides & recordings

Keynote – Josh Mandel, MD

FHIR: Interop for Consumer Access, Clinical Research, and Beyond: As Chief Architect for Microsoft Healthcare, Chief Architect for SMART Health IT, and Lecturer at the Harvard Medical School Department of Biomedical Informatics, Josh works closely with the standards development community to lay groundwork for frictionless data access, authorization, analytics, and app integration.

If you attended this years virtual event, please let us know what you thought. Click the button below for a short survey.

event survey

Nominations are now being accepted.

Foundation Board of Directors has one seat is open.

See the Nomination Form below more information on this two year position

Nominatation Form

Current Board Members can be found here

Isaac Kohane, MD Ph D

Professor & Chair of the Department of Biomedical Informatics at Harvard Medical School

Board Chairman of the i2b2 tranSMART Foundation

more about Dr. Kohane

A Message from Isaac Kohane

Right from the start, in March 2020, it was clear that there were going to be numerous international research studies collecting and analyzing data on COVID-19 patients. But those of us with experience with system-wide data, particularly EHR-derived data knew that we were facing a tall order. We had to move fast because the need was urgent. Yet, given the heterogeneity of our institutions and practices, how could we develop a reliable big picture of what was happening to our patients? Launched in March, 2020, 4CE is a unique project that engages local experts in informatics, statistics and clinical medicine at more than 350 hospitals across 9 countries on 4 continents to iteratively improve sites’ data quality, understand the limitations of EHR data on COVID-19 patients, and conduct rapid analyses through a federated model that reduces barriers to participation. We believe that early intelligence is worth more than complete intelligence later. Our goal is to move quickly, publish results, and share lessons learned with others.

COVID-19 4CE Consortium

Dr. Zak Kohane and several members of our Board of Directors have launched an urgent initiative with organizations around the world to rapidly collect aggregate data on hospitalized patients that are COVID-19 positive. The goal of this effort is to quickly collect data and publish the results.
Consortium for Clinical Characterization of Covid19 by EHR (4CE)

In this time of great need, the i2b2 tranSMART Foundation and the i2b2 community are working to combine national and international data for analyses of the COVID-19 affliction on our patients.

The 4CE Consortium is a globally distributed collaboration across health centers. In this first phase we are reaching out to other collaborators to join our 96 hospital collaboration who also have EHR data to share to augment the breadth and depth of the analyses we jointly work on.

Connect to 4CE

About the i2b2 tranSMART Foundation


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Diane Keogh
Executive Director

From The Executive Director’s Desk

COVID-19 Action!

In this time of great need, the i2b2 community is working to combine national and international analyses of the COVID-19 affliction on our patients.

There are two major initiatives that the Foundation is participating in at this time.

Grant to the Foundation from Dell Technologies

First, we are delighted to announce that Dell Technologies has given the Foundation a significant grant to expedite three projects that are focused on COVID-19 research working towards better understanding diagnosis, treatment and prevention of the disease. The three projects will be described in detail in upcoming Community Meetings. They are:

  • Public tranSMART v19 platform running on AWS with datasets that become publicly available. This project is in collaboration with Axiomedix.
  • With the explosion of articles and research labs studying the corona virus (over 6,000 articles from 25,000 authors), a special version of Profiles is being developed by Griffin Weber and will be available publicly.
  • i2b2 and tranSMART are being synchronized to the same data model so that direct data sharing will be possible between the Foundation platforms. We will have a few use cases and sample deployments available in the coming months.

4CE Consortium

Second, I want to tell you about the 4CE Consortium that was launched by Dr. Zak Kohane and several members of our Board of Directors. This urgent initiative with organizations around the world allowed labs with i2b2 to rapidly collect aggregate data on hospitalized patients that are COVID-19 positive. Their first publication is available as a preprint (click here) and will be published soon.

i2b2 ACT COVID ontology that has been developed

An initial ACT COVID ontology has been developed by the ACT Harmonization Committee. Note: Implementing this ontology is not necessary for this initial submission, but it might be helpful for you to look at the codes it uses as you try to identify your population of COVID-19 positive patients. click here for ACT COVID ontology

More information will be published here on our website as it becomes available. Be sure to join our Community Meetings and please attend the 2020 Harvard Virtual Symposium which will include focused sessions on these and other COVID-19 related projects.


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Register now! 4CE International Consortium for Clinical Characterization of COVID-19 by EHR. Join us to discover how this international effort moved rapidly to inform healthcare professionals about COVID-19 patients. #clinicalresearch #Epidemiology

Community Meeting Today at 11:00 AM EST. Updates on the 4CE November Symposium and Nich Wattanasin will give a live demo of the new open source i2b2 ontology editing tool. Join us - zoom meeting link

i2b2 tranSMART Foundation in collaboration with Dell Technologies - Use advanced AI to create a digital twin database to help researchers study long-haul COVID-19. #COVID19 #LongCovid #AI #digitaltwin

User Interface Working Group meets tomorrow 8/18 from 11-12pm EST. @kaviWagholikar will be presenting a simplified ETL-i2b2 model and UI, REST swagger UI and population facts and tabulation UI. Join us #ETL #EHR #i2b2

InterSystems IRIS Open platform supporting FHIR standards. Long COVID June Symposium recording All recordings can be found here #LongCovid #OpenSource #FHIR

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